ACCE anastrozole aromatase inhibitors blood clots breast cancer cancer risk cash based practice concierge medicine conjugated equine estrogens CVD deep venous thrombosis direct primary care DVT e2 estradiol gynecomastia low free T3 medical business model medroxyprogesterone natural hormones nurse practitioner oral estradiol oral estrogen PCSK-9 Inhibitors PE physician burnout polypharmacy practice transition premarin prevent heart disease pulmonary embolism reverse diabetes root cause sickness medicine synthetic hormones T4 Monotherapy testosterone testosterone in men thyroid thyroid optimization transdermal estrogen TSH wellness medicine whi women's health initiative